Prof. Mizuguchi leads research that integrates informatics and computational chemistry to uncover the mechanisms of diseases and apply findings to drug discovery. His lab focuses on integrating diverse biological data—from genes and proteins to diseases and compounds—to power AI-driven analysis.

He also develops predictive models for protein structure, function, and interactions, with applications in fields like immunology and developmental biology, as well as early-stage drug profiling.

Prof. Kazuhiko Nakatani is a leading expert in developing small molecules that target nucleic acids, focusing on those that recognize mismatched base pairs in triplet repeat sequences implicated in neurodegenerative diseases.

Recently, Nakatani group explore AI and computer-aided approaches in drug discovery research, advancing the design of novel therapeutic candidates.

Dr. Yamada Takeshi is a specialist in synthetic organic chemistry, chemical biology, and nucleic-acid drug development, serving as a lecturer at the Nucleotide and Peptide Drug Discovery Center (TIDE), Tokyo University of Science. His research focuses on designing antisense oligonucleotides (ASOs) and heteroduplex oligonucleotides (HDOs), particularly improving drug-delivery systems and pharmacokinetics to advance nucleic-acid therapeutics. He aims to contribute to next-generation treatments for challenging diseases through innovative oligonucleotide-based drugs.

Recently, Nakatani group explore AI and computer-aided approaches in drug discovery research, advancing the design of novel therapeutic candidates.